Gradient-enhanced Kriging (GE-Kriging) is a well-established surrogate modelling technique for approximating expensive computational models. However, it tends to get impractical for high-dimensional problems due to the large inherent correlation matrix and the associated high-dimensional hyper-parameter tuning problem. To address these issues, we propose a new method in this paper, called sliced GE-Kriging (SGE-Kriging) for reducing both the size of the correlation matrix and the number of hyper-parameters. Firstly, we perform a derivative-based global sensitivity analysis to detect the relative importance of each input variable with respect to model response. Then, we propose to split the training sample set into multiple slices, and invoke Bayes' theorem to approximate the full likelihood function via a sliced likelihood function, in which multiple small correlation matrices are utilized to describe the correlation of the sample set. Additionally, we replace the original high-dimensional hyper-parameter tuning problem with a low-dimensional counterpart by learning the relationship between the hyper-parameters and the global sensitivity indices. Finally, we validate SGE-Kriging by means of numerical experiments with several benchmarks problems. The results show that the SGE-Kriging model features an accuracy and robustness that is comparable to the standard one but comes at much less training costs. The benefits are most evident in high-dimensional problems.

Classically, the development of humanoid robots has been sequential and iterative. Such bottom-up design procedures rely heavily on intuition and are often biased by the designer's experience. Exploiting the non-linear coupled design space of robots is non-trivial and requires a systematic procedure for exploration. We adopt the top-down design strategy, the V-model, used in automotive and aerospace industries. Our co-design approach identifies non-intuitive designs from within the design space and obtains the maximum permissible range of the design variables as a solution space, to physically realise the obtained design. We show that by constructing the solution space, one can (1) decompose higher-level requirements onto sub-system-level requirements with tolerance, alleviating the "chicken-or-egg" problem during the design process, (2) decouple the robot's morphology from its controller, enabling greater design flexibility, (3) obtain independent sub-system level requirements, reducing the development time by parallelising the development process.

Artificial Intelligence (AI) has become commonplace to solve routine everyday tasks. Because of the exponential growth in medical imaging data volume and complexity, the workload on radiologists is steadily increasing. We project that the gap between the number of imaging exams and the number of expert radiologist readers required to cover this increase will continue to expand, consequently introducing a demand for AI-based tools that improve the efficiency with which radiologists can comfortably interpret these exams. AI has been shown to improve efficiency in medical-image generation, processing, and interpretation, and a variety of such AI models have been developed across research labs worldwide. However, very few of these, if any, find their way into routine clinical use, a discrepancy that reflects the divide between AI research and successful AI translation. To address the barrier to clinical deployment, we have formed MONAI Consortium, an open-source community which is building standards for AI deployment in healthcare institutions, and developing tools and infrastructure to facilitate their implementation. This report represents several years of weekly discussions and hands-on problem solving experience by groups of industry experts and clinicians in the MONAI Consortium. We identify barriers between AI-model development in research labs and subsequent clinical deployment and propose solutions. Our report provides guidance on processes which take an imaging AI model from development to clinical implementation in a healthcare institution. We discuss various AI integration points in a clinical Radiology workflow. We also present a taxonomy of Radiology AI use-cases. Through this report, we intend to educate the stakeholders in healthcare and AI (AI researchers, radiologists, imaging informaticists, and regulators) about cross-disciplinary challenges and possible solutions.

This study introduces and examines the potential of an AI system to generate health awareness messages. The topic of folic acid, a vitamin that is critical during pregnancy, served as a test case. Using prompt engineering, we generated messages that could be used to raise awareness and compared them to retweeted human-generated messages via computational and human evaluation methods. The system was easy to use and prolific, and computational analyses revealed that the AI-generated messages were on par with human-generated ones in terms of sentiment, reading ease, and semantic content. Also, the human evaluation study showed that AI-generated messages ranked higher in message quality and clarity. We discuss the theoretical, practical, and ethical implications of these results.

Accurate PhotoVoltaic (PV) power generation forecasting is vital for the efficient operation of Smart Grids. The automated design of such accurate forecasting models for individual PV plants includes two challenges: First, information about the PV mounting configuration (i.e. inclination and azimuth angles) is often missing. Second, for new PV plants, the amount of historical data available to train a forecasting model is limited (cold-start problem). We address these two challenges by proposing a new method for day-ahead PV power generation forecasts called AutoPV. AutoPV is a weighted ensemble of forecasting models that represent different PV mounting configurations. This representation is achieved by pre-training each forecasting model on a separate PV plant and by scaling the model's output with the peak power rating of the corresponding PV plant. To tackle the cold-start problem, we initially weight each forecasting model in the ensemble equally. To tackle the problem of missing information about the PV mounting configuration, we use new data that become available during operation to adapt the ensemble weights to minimize the forecasting error. AutoPV is advantageous as the unknown PV mounting configuration is implicitly reflected in the ensemble weights, and only the PV plant's peak power rating is required to re-scale the ensemble's output. AutoPV also allows to represent PV plants with panels distributed on different roofs with varying alignments, as these mounting configurations can be reflected proportionally in the weighting. Additionally, the required computing memory is decoupled when scaling AutoPV to hundreds of PV plants, which is beneficial in Smart Grids with limited computing capabilities. For a real-world data set with 11 PV plants, the accuracy of AutoPV is comparable to a model trained on two years of data and outperforms an incrementally trained model.

Recently, RNN-Transducers have achieved remarkable results on various automatic speech recognition tasks. However, lattice-free sequence discriminative training methods, which obtain superior performance in hybrid modes, are rarely investigated in RNN-Transducers. In this work, we propose three lattice-free training objectives, namely lattice-free maximum mutual information, lattice-free segment-level minimum Bayes risk, and lattice-free minimum Bayes risk, which are used for the final posterior output of the phoneme-based neural transducer with a limited context dependency. Compared to criteria using N-best lists, lattice-free methods eliminate the decoding step for hypotheses generation during training, which leads to more efficient training. Experimental results show that lattice-free methods gain up to 6.5% relative improvement in word error rate compared to a sequence-level cross-entropy trained model. Compared to the N-best-list based minimum Bayes risk objectives, lattice-free methods gain 40% - 70% relative training time speedup with a small degradation in performance.

The need for data privacy and security -- enforced through increasingly strict data protection regulations -- renders the use of healthcare data for machine learning difficult. In particular, the transfer of data between different hospitals is often not permissible and thus cross-site pooling of data not an option. The Personal Health Train (PHT) paradigm proposed within the GO-FAIR initiative implements an 'algorithm to the data' paradigm that ensures that distributed data can be accessed for analysis without transferring any sensitive data. We present PHT-meDIC, a productively deployed open-source implementation of the PHT concept. Containerization allows us to easily deploy even complex data analysis pipelines (e.g, genomics, image analysis) across multiple sites in a secure and scalable manner. We discuss the underlying technological concepts, security models, and governance processes. The implementation has been successfully applied to distributed analyses of large-scale data, including applications of deep neural networks to medical image data.

Because of their close relationship with humans, non-human apes (chimpanzees, bonobos, gorillas, orangutans, and gibbons, including siamangs) are of great scientific interest. The goal of understanding their complex behavior would be greatly advanced by the ability to perform video-based pose tracking. Tracking, however, requires high-quality annotated datasets of ape photographs. Here we present OpenApePose, a new public dataset of 71,868 photographs, annotated with 16 body landmarks, of six ape species in naturalistic contexts. We show that a standard deep net (HRNet-W48) trained on ape photos can reliably track out-of-sample ape photos better than networks trained on monkeys (specifically, the OpenMonkeyPose dataset) and on humans (COCO) can. This trained network can track apes almost as well as the other networks can track their respective taxa, and models trained without one of the six ape species can track the held out species better than the monkey and human models can. Ultimately, the results of our analyses highlight the importance of large specialized databases for animal tracking systems and confirm the utility of our new ape database.

Air pollution is a crucial issue affecting human health and livelihoods, as well as one of the barriers to economic and social growth. Forecasting air quality has become an increasingly important endeavor with significant social impacts, especially in emerging countries like China. In this paper, we present a novel Transformer architecture termed AirFormer to collectively predict nationwide air quality in China, with an unprecedented fine spatial granularity covering thousands of locations. AirFormer decouples the learning process into two stages -- 1) a bottom-up deterministic stage that contains two new types of self-attention mechanisms to efficiently learn spatio-temporal representations; 2) a top-down stochastic stage with latent variables to capture the intrinsic uncertainty of air quality data. We evaluate AirFormer with 4-year data from 1,085 stations in the Chinese Mainland. Compared to the state-of-the-art model, AirFormer reduces prediction errors by 5%~8% on 72-hour future predictions. Our source code is available at https://github.com/yoshall/airformer.

This paper presents a two-step algorithm for online trajectory planning in indoor environments with unknown obstacles. In the first step, sampling-based path planning techniques such as the optimal Rapidly exploring Random Tree (RRT*) algorithm and the Line-of-Sight (LOS) algorithm are employed to generate a collision-free path consisting of multiple waypoints. Then, in the second step, constrained quadratic programming is utilized to compute a smooth trajectory that passes through all computed waypoints. The main contribution of this work is the development of a flexible trajectory planning framework that can detect changes in the environment, such as new obstacles, and compute alternative trajectories in real time. The proposed algorithm actively considers all changes in the environment and performs the replanning process only on waypoints that are occupied by new obstacles. This helps to reduce the computation time and realize the proposed approach in real time. The feasibility of the proposed algorithm is evaluated using the Intel Aero Ready-to-Fly (RTF) quadcopter in simulation and in a real-world experiment.